Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma. Genetics and epigenetics of human retinoblastoma. Targeting the DNA repair pathway in Ewing sarcoma. Cross-species genomic and epigenomic landscape of retinoblastoma. Faculty of F NAD in skin: therapeutic approaches for niacin.
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Subcellular distribution and mitogenic effect of basic fibroblast growth factor in mesenchymal uncommitted stem cells. In humans, a small clinical research study showed the relationship between prenatal exposure to maternal mood and genetic expression resulting in increased reactivity to stress in offspring. Recent research has also shown the relationship of methylation of the maternal glucocorticoid receptor and maternal neural activity in response to mother-infant interactions on video.
A review discusses the role of DNA methylation in memory formation and storage, but the precise mechanisms involving neuronal function, memory, and methylation reversal remain unclear. Studies in rodents have found that the environment exerts an influence on epigenetic changes related to cognition , in terms of learning and memory;  environmental enrichment correlated with increased histone acetylation , and verification by administering histone deacetylase inhibitors induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories.
Environmental and epigenetic influences seem to work together to increase the risk of addiction. Even short-term substance abuse can produce long-lasting epigenetic changes in the brain of rodents,  via DNA methylation and histone modification. In turn, increased substance abuse results in even greater epigenetic changes in various components of a rodent's reward system  e.
Hence, a cycle emerges whereby changes in the pleasure-reward areas contribute to the long-lasting neural and behavioural changes associated with the increased likelihood of addiction, the maintenance of addiction and relapse. As such, epigenetic modifications may play a part in the progression from the controlled intake to the loss of control of alcohol consumption. These include: repetitive habits that increase the risk of disease, and personal and social problems; need for immediate gratification ; high rates of relapse following treatment; and, the feeling of loss of control.
Evidence for related epigenetic changes has come from human studies involving alcohol,  nicotine, and opiate abuse. Evidence for epigenetic changes stemming from amphetamine and cocaine abuse derives from animal studies. In animals, drug-related epigenetic changes in fathers have also been shown to negatively affect offspring in terms of poorer spatial working memory , decreased attention and decreased cerebral volume.
Epigenetic changes may help to facilitate the development and maintenance of eating disorders via influences in the early environment and throughout the life-span. These anxiety issues can precipitate the onset of eating disorders and obesity , and persist even after recovery from the eating disorders.
Epigenetic differences accumulating over the life-span may account for the incongruent differences in eating disorders observed in monozygotic twins. At puberty , sex hormones may exert epigenetic changes via DNA methylation on gene expression, thus accounting for higher rates of eating disorders in men as compared to women.
Overall, epigenetics contribute to persistent, unregulated self-control behaviours related to the urge to binge. Epigenetic changes including hypomethylation of glutamatergic genes i. Epigenetic changes affecting a greater number of genes have been detected in men with schizophrenia as compared to women with the illness. Population studies have established a strong association linking schizophrenia in children born to older fathers.
This provides a possible explanation for increased rates of the disease in men. Animals exposed to ambient air from steel mills and highways show drastic epigenetic changes that persist after removal from the exposure. As such, many other environmental factors e. Evidence for epigenetic modifications for bipolar disorder is unclear.
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COMT is an enzyme that metabolizes dopamine in the synapse. These findings suggest that the hypomethylation of the promoter results in over-expression of the enzyme. In turn, this results in increased degradation of dopamine levels in the brain. These findings provide evidence that epigenetic modification in the prefrontal lobe is a risk factor for bipolar disorder.
The causes of major depressive disorder MDD are poorly understood from a neuroscience perspective. Much of the work in animal models has focused on the indirect downregulation of brain derived neurotrophic factor BDNF by over-activation of the stress axis. Epigenetics may be relevant to aspects of psychopathic behaviour through methylation and histone modification.
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A study of the brains of 24 suicide completers, 12 of whom had a history of child abuse and 12 who did not, found decreased levels of glucocorticoid receptor in victims of child abuse and associated epigenetic changes. Several studies have indicated DNA cytosine methylation linked to the social behavior of insects, such as honeybees and ants. In honeybees, when nurse bee switched from her in-hive tasks to out foraging, cytosine methylation marks are changing.
When a forager bee was reversed to do nurse duties, the cytosine methylation marks were also reversed. Many researchers contribute information to the Human Epigenome Consortium.
More collaboration between medical researchers, geneticists and social scientists has been advocated to increase knowledge in this field of study. Limited access to human brain tissue poses a challenge to conducting human research. Some researchers note that epigenetic perspectives will likely be incorporated into pharmacological treatments.
If such treatable patterns eventually become well-established, the inability to access brains in living humans to identify them poses an obstacle to pharmacological treatment. Most epigenetic research is correlational; it merely establishes associations. More experimental research is necessary to help establish causation.
From Wikipedia, the free encyclopedia. Main article: Epigenetics. Signaling cascade in the nucleus accumbens that results in psychostimulant addiction v t e. Note: colored text contains article links. Nuclear pore.
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Nuclear membrane. Plasma membrane. Further information: Epigenetics of schizophrenia. The seductive allure of behavioral epigenetics". Bibcode : Sci Toronto: Pearson Education Canada. Oxford University Press. Current Directions in Psychological Science. Worringer, Barbara Panning. Chromatin Mechanisms in Drosophila Dosage Compensation. Seed Development and Genomic Imprinting in Plants. Back Matter Pages About this book Introduction Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence.
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